A hip replacement is designed to last for many years, but in some cases a second operation may be needed. One of the most common reasons is a periprosthetic joint infection (PJI). Although infections after hip replacement are uncommon, they require prompt treatment to protect the joint and restore mobility.
When an infection is confirmed, one of the key decisions is whether to perform a one-stage or two-stage revision. Both approaches aim to remove the infection and restore function, but they involve different surgical pathways. The right choice depends on the type of bacteria involved, the condition of the surrounding bone and soft tissues, and the patient’s overall health.
What is the difference between a one-stage and two-stage revision hip replacement?
A one-stage revision involves removing the infected implant, thoroughly cleaning the joint, and inserting a new hip replacement in the same operation, followed by antibiotics and rehabilitation.
A two-stage revision separates this into two operations. The implant is first removed and the joint cleaned, with an antibiotic-loaded spacer placed temporarily while a course of antibiotics is completed. Once the infection has cleared, a second operation inserts the new replacement.
Which approach is recommended?
One-stage revision is increasingly considered for carefully selected patients where the bacteria have been identified, soft tissues are in good condition, and the patient is medically stable. Avoiding a second major operation can shorten recovery and reduce time in hospital.
Two-stage revision remains the preferred option for more complex cases, including resistant bacteria, significant bone loss, or where the infecting organism is unknown. It is a well-established approach for managing difficult infections and continues to deliver reliable outcomes.
What does the research show?
Mr Alazzawi recently co-authored a 2025 study in Orthopedic Reviews examining long-term outcomes of single-stage versus two-stage revision for prosthetic joint infection, comparing infection clearance and treatment failure rates in demographically similar patient groups.
Separately, emerging 2025 evidence suggests that one-stage revision can achieve comparable infection control to two-stage procedures in appropriately selected patients, with the added benefits of fewer operations and faster rehabilitation. The INFORM trial, the first multicentre randomised controlled trial directly comparing both approaches, is currently recruiting and is expected to provide more detailed guidance on outcomes, quality of life, and cost-effectiveness.
As understanding of periprosthetic joint infection improves, treatment is becoming increasingly personalised. Whether one-stage or two-stage revision is recommended, the goal is the same: to eliminate infection, restore movement, and return patients to an active life.
If you have concerns about a previous hip replacement or have been diagnosed with a periprosthetic joint infection, Mr Alazzawi has extensive expertise in complex revision surgery and can provide a thorough assessment to determine the most appropriate treatment for your circumstances. Get in touch to book a consultation.

